Eddie Campbell was born in Glasgow, Scotland, but has lived in Australia for many years. He began his career in the alternative comix scene of the 1970s and 1980s, publishing fanzines like Fast Fiction!, Gag! and Flick. Until the early 1990s, he contributed to reviews like Escape and Knockabout, and to the independent publishers Mad Dog, Fantagraphics, ACME Press, and Aardvark/Vanaheim. He dealt with this era in his story 'How to be an Artist', which was published in The Staros Report and Dee Vee from 1997.
He subsequently wrote 'Lucifer', illustrated by Phill Elliot and Paul Grist, and published by Harrier Comics, as well as 'Hellblazer', with art by Sean Phillips at DC/Vertigo. In 1998, he cooperated on 'The Spirit: The New Adventures' with the classic Will Eisner character at Kitchen Sink. In 1987, he created 'Bacchus', a character of over 4,000 years.
He made this series on his own, and later with artist Pete Mullins, in several publications of Harrier Comics and Dark Horse, such as Deadface, Trident, Dark Horse Presents and The Eyeball Kid. He began a monthly, self-published, comic book with the character in 1995. Around the same time, Campbell created his own label, called Eddie Campbell Comics, where he reprinted 'Bacchus' and where he began working on a series on autobiographical comics.
Campbell has cooperated on several outstanding productions with the writer Alan Moore since the late 1980s. Together, they made 'From Hell' for the Australian magazine Taboo. The publication of this comic, about Jack the Ripper, was cancelled in 1992 because it was too violent, but did find its way to the audience through comic books published by Mad Love/Tundra and Mad Love/Kitchen Sink.
It won the Ignatz Award for "Outstanding Graphic Novel Or Collection" at the Small Press Expo 2000 and the Eisner Award for Best Graphic Album (Reprint). It was made into a movie that debuted in October, 2001. Campbell and Moore then cooperated on 'The Birth Caul' and 'Snakes & Ladders'. Eddie Campbell launched the magazine Egomania in 2002.