Régis Loisel is one of main and first French authors that have worked in the fantasy genre since the 1970s. The style that Loisel used for his famous series 'La Quete de l'Oiseau du Temps' has become a standard for the European artists that work in this genre. In 1972, Loisel made his debut in the magazine Pieds Nickelés, while attending comics courses in Vincennes. From 1974, he was present in Mormoil and Pilote. In the following year, he joined Serge Le Tendre in the creation of a first version of 'La Quête de l'Oiseau du Temps' in Imagine.
He worked with Patrick Cothias on 'Capitaine Kergenec' (in Pif Gadget), 'Norbert le Lézard' in Plop and on the creation of Tousse-Bourin magazine. His fantasy stories for this magazine were collected in the album 'Nocturnes' (Kesselring, 1978). Loise made occasional appearances in Métal Hurlant and Fluide Glacial, and started the atelier Bergame with Olivier Taffin, Michel Rouge and Fabien Lacaf. In cooperation with Taffin, he illustrated 7 pantomime comic strips that came with Malabar chewing gum in 1983.
A new version of 'La Quête de l'Oiseau du Temps' was launched in Charlie Mensuel in 1982. Albums were published by Dargaud. In the 1980s, he also produced illustration portfolios, such as 'L'Offrande' (Trihan, 1984) and 'Troubles Fêtes' (Les Humanoïdes Associés, 1989). In 1990, he started his second popular serial, 'Peter Pan', which is a mix of the classical adventure story with a Dickensian story of an orphan. In 1993, he made 'La Dernière Goutte' with G.P. Taladiart for La Sirène and 'Les Petits Rêveurs' in the collection Grain de Sable of Vents d'Ouest.
In the late 1990s, Loisel and Le Tendre launched a spin-off series of 'L'Oiseau du Temps', called 'L'Ami Javin', for which they wrote the scripts together and left the artwork to Lidwine. Loisel also proved a versatile writer for other artists, namely Philippe Sternis ('Pyrénée', 1998), Christine Oudot ('Fanfreluches pour une Sirène', 2001), Pierre Guilmard ('Les Farfelingues', 2001-04) and Vincent Mallié ('Le Grand Mort', 2007, co-written by Djian).
In 2000, Loisel made 'Mali Mélo - Carnet d'un Voyage', based on his experiences during a trip through Africa (co-scripted by Yvon Le Corre and Serge Le Tendre). In the following year, he produced 'Personnel' and 'Triptyque' for Granit Éditions. In 2006 he teamed up with Jean-Louis Tripp to create 'Magasin General', a poetic series set in a small town in 1940s Quebec. For this series, that is published by Casterman, the artists developed a joint style, with Loisel doing the pencil work, Tripp the finished art and François Lapierre the colors. In addition to comics, Loisel has also cooperated on the Disney animation films 'Mulan' and 'Atlantis', as well as Olivier Dahan's 'Petit Poucet'.